What are the most common side effects of semaglutide?

The most common side effects are GI related: nausea, vomiting, diarrhea, constipation, and sometimes heartburn or bloating. These usually improve as your body adjusts, especially when your provider follows a slow dose‑escalation schedule. Eating smaller meals, avoiding very fatty foods, and staying hydrated can help. Serious side effects are rare but can include pancreatitis, gallbladder issues, or allergic reactions. Always tell your provider about any severe or persistent symptoms.